题目：Discovering Microbial Potential to Remediate Groundwater Contamination
报告人：Nannan Jiang（University of Tennessee）
Nannan Jiang is fortunate to be a fellow of the National Science Foundation’s East Asia and Pacific Summer Institutes (NSF EAPSI). This fellowship program provides opportunities for U.S. graduate students to perform research overseas in countries including Australia, China, Japan, Korea, New Zealand, Singapore and Taiwan. International collaboration is paramount to address global concerns such as environmental sustainability. Nannan is excited for the opportunity to work alongside the team at the Institute of Applied Ecology with the guidance of Professors Yufang Song and Jun Yan. Prior to joining Professor Frank E. Löffler’s group, Nannan earned a B.S. in Biology from Purdue University and a M.S. in Microbiology from the University of Illinois at Urbana-Champaign.
With the rise of the human population as well as industrial and agricultural activities, global sustainability is becoming an increasingly critical issue. Environmental pollutants threaten our environmental sustainability. One class of contaminants is the chlorinated solvents, which are toxic and sometimes carcinogenic compounds frequently found in groundwater systems worldwide. Bioremediation techniques including bioaugmentation and biostimulation have using the bacterium Dehalococcoides have proven effective in decreasing chlorinated solvent contamination. Recent studies have shown that the enzymes responsible for the degradation of these chlorinated solvents are entirely dependent on a unique corrinoid cofactor, such as vitamin B12. However, the corrinoid cofactors can differ at the level of the lower base, which can impact dechlorination activity. By coupling comparative genomics and genetic engineering, we have identified a gene responsible for synthesizing a lower base that is known to support reductive dechlorination in Dehalococcoides. Additionally, we will present our proposal to collaborate with key professors at the Institute of Applied Ecology to explore the bioremediation potential and possible resistance mechanisms of microorganisms found in contaminated environments.